We dealt with one threat to the ozone layer, which is still recovering to its prior state and will take decades longer to do so all other things being equal. Except that all other things will not be equal due to the climate changing, and we may yet see it degraded from other processes to create a hole over the Arctic soon. A hole over the Arctic would have a much larger effect on human populations.

https://www.climate.gov/news-features/understanding-climate/...

https://www.eea.europa.eu/en/topics/in-depth/climate-change-...

And a little explainer video on the complexities of differing temperatures at different layers of the atmosphere.

https://www.youtube.com/watch?v=y35Lzgc9iJk