'NOT flair:meme'
For example: https://www.reddit.com/r/help/search/?q=NOT%20flair%3AAccess...
You won't see any of the posts titled 'Access' in that search.
On old.reddit a number of subs that I followed had those as quick links (e.g. a "click here to see /r/cats without posts flared 'mourning or loss'")
The easiest solution seems to be to allow filtering of content based on tags. In most cases, the memes were tagged as such. Had I been able to simply say, "Don't show content with the `meme` tag," I probably would have spent a good deal more time on reddit, browsing and contributing.