Open office layouts can be hard to deal with for me, even if everything else (chair, desk, computer, etc) are good. It varies from day to day but there are days where it's practically impossible to think due to coworkers buzzing around like bees, popping in and out of peripheral vision. When that happens, putting on ANC headphones is like trying to patch a basketball-sized hole in a boat with a piece of chewing gum.

Working from home there are still days when focusing is difficult, but nothing as frustrating as that.