Whataboutism but puts those numbers in perspective.
Guns… most of those are suicides, and that stat is uniquely American in terms of developed countries.
Opioids… also almost entirely self-inflicted (not willingly, but getting flattened by a bus is different than getting accidentally hooked)
Car stats also don’t count the incredible number of people who have lifelong or major injuries due to cars, which I would imagine is much higher. I feel pretty comfortable saying that a majority of people I know have been injured by cars, something that isn’t true for opioids or guns.
That seemed unbelievable to me, so I had to do some checking. The CDC[0] put 48k suicides in 2021, and attributed 55% to guns. Leaving us with 26.4k suicide gun deaths. While still a large number, there are still a significant portion of GP's 48k gun deaths which were not self inflected.
[0] https://www.cdc.gov/suicide/suicide-data-statistics.html