Guix has more stuff in it now than Nixpkgs did when I started daily driving NixOS. I'd say it's quite usable, especially if you're willing to package whatever extras you need.

Encouragingly, as well, the Guix package collection is growing at an exponential rate (as is Nixpkgs). In a few years there'll be twice as many packages or more, so if you can make it work now, it won't be tough to stick with it.