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Re:Man Cures Acid Reflux By Eating Upside-Down by killjoywashere on Wednesday May 24, 2023 @12:06PM (#36060055)
Uh, there's likely more than a few confounders here, which are, at a minimum, undocumented in the report. Intuitively, one would expect lower caloric consumption with altered eating habits, which would lead to decreased fat and decreased intra-abdominal pressure. There's also no test of LES function prior to initiation of the experiment, so no delta was actually measured.

There's also a bit of misunderstanding, I suspect, in the pathology report: 0.2 x 0.5 x 0.3 cm is a perfectly reasonable size for an esophageal biopsy, and it was almost certainly measured with a ruler like (1) or (2).

I've passed this to a GI friend to get their thoughts, but suffice to say, more study is required before making this any sort of recommendation.

(1) https://www.neobits.com/thermo_fisher_scientific_nc9759439_r...

(2) https://www.aaawholesalecompany.com/fis-s40641-pk.html

Re:Man Cures Acid Reflux By Eating Upside-Down by Eisenstein on Wednesday May 24, 2023 @12:30PM (#36060489)
I look forward to hearing what your colleague reports.
Re:Man Cures Acid Reflux By Eating Upside-Down by killjoywashere on Wednesday May 24, 2023 @04:24PM (#36063418)
I quote: "Just what everyone wants upside down LES kegels <laughing to tears emoji>"
Re:Man Cures Acid Reflux By Eating Upside-Down by conformist on Wednesday May 24, 2023 @05:22PM (#36064023)
It’s great that he wrote it up in such a nice format so others can now run more sophisticated studies.

Imo journals should encourage such articles along the lines of “here’s a neat idea that we tried and that appears somewhat plausible, and we’re not even going to pretend to do statistics”.

Re:Man Cures Acid Reflux By Eating Upside-Down by basiskarten on Wednesday May 24, 2023 @06:05PM (#36064447)
Valid points but strategies with low or no risk can be recommended to try even with very little evidence.