News for hackers. Stuff that matters.
Re:Ozempic drug supresses desire to smoke, drink and more by BizarroLand on Friday May 19, 2023 @12:38PM (#36003890)
You can buy it as a "research chemical" and save money, but then the potential consequences of diy medicine and all that that entails are all on you.

Hopefully the price will come down more as it becomes more prevalent or as generics become available.

Re:Ozempic drug supresses desire to smoke, drink and more by rektide on Friday May 19, 2023 @12:43PM (#36003951)
I'm not that afraid of swallowing random chemicals but self injecting is a bit hardcore for me.
Re:Ozempic drug supresses desire to smoke, drink and more by EthicalSimilar on Friday May 19, 2023 @01:05PM (#36004287)
FWIW, SubQ injections are pretty much completely unnoticeable in terms of pain / feeling at all. It’s more the mental barrier of doing it to yourself but once you’ve done it for the first time you soon realise it’s fine.
Re:Ozempic drug supresses desire to smoke, drink and more by rektide on Friday May 19, 2023 @01:33PM (#36004617)
The actual doing it seems wild/absurd, but I don't think that would hold me back.

This is ignorant/uniformed, but, taking research chemical by ingestion feels like I have some natural barriers still. Where-as I feel like there's a much more raw exposure to risk with injection. Also there's dumb risks like infection, if I don't attend well enough to injections.

In spite of these protests, I think you are probably much closer to the truth here. Thanks for writing. These reactions I have are, I suspect, not really significant.

Re:Ozempic drug supresses desire to smoke, drink and more by idontwantthis on Friday May 19, 2023 @10:42PM (#36008926)
Counterpoint: Don’t inject yourself with stuff you found on the internet because people on the internet told you it’s ok.
Re:Ozempic drug supresses desire to smoke, drink and more by opportune on Friday May 19, 2023 @04:17PM (#36006369)
Steroid users do it all the time and I haven’t heard of steroid users dealing with infections much.
Re:Ozempic drug supresses desire to smoke, drink and more by pixl97 on Friday May 19, 2023 @07:04PM (#36007812)
I'm sure its because most people aren't going to talk about illegal drug use and when it goes wrong.
Re:Ozempic drug supresses desire to smoke, drink and more by opportune on Sunday May 21, 2023 @10:07PM (#36026625)
There are tons of online places where people openly discuss steroid use like r/steroids and many oldschool phpbb-style steroid forums
Re:Ozempic drug supresses desire to smoke, drink and more by scheme271 on Friday May 19, 2023 @12:44PM (#36003993)
GLP-1 agonists are a bit more tricky since they are temperature sensitive and need to be injected. You'll really need to be careful to keep it sterile and handle it properly. Whether the "research chemical" will receive the proper care until it gets into your hands is something that you're literally gambling your health on.
Re:Ozempic drug supresses desire to smoke, drink and more by reaperman on Friday May 19, 2023 @09:26PM (#36008588)
You ship it as a dry/lypohilized powder, both semaglutide and tirzepatide survives long China->Europe shipping in the summer just fine, with customs delays. The testing I've seen showed 99.965% purity of semaglutide after 22 days in shipping from China to Poland during April. Tirzepatide shows 99.064% purity after 58 days of shipping in October-November.

You reconstitute it with Bacteriostatic Water which is available without a prescription in the USA and contains 0.9% benzyl alcohol to inhibit bacterial growth.

If you're particularly concerned you buy a 0.22 micrometer PVDF "syringe filter" and pump it through that to another, fresh/sealed sterile vial which you can get for like $2.00 from a medical supply company (the syringe, filter, and vials are gamma-irradiated to destroy any remnants of RNA/DNA). That size filtration will filter out any lifeforms (fungal, bacterial, viral) while allowing the peptide/drug itself to pass through. So you get a guaranteed sterile solution out of the filter.

Re:Ozempic drug supresses desire to smoke, drink and more by quazar on Friday May 19, 2023 @10:18PM (#36008822)
Where do you buy it from to ship to Poland?
Re:Ozempic drug supresses desire to smoke, drink and more by reaperman on Friday May 19, 2023 @11:54PM (#36009239)
Anything specific would be inappropriate for this forum. But the broad answer is a chemicals distributor in China. I actually only utilize them for legal "nutritional" compounds, but others use them for pharmaceutical options, and those are independently tested frequently by a variety of stakeholders. Personally I really wish US citizens didn't feel forced to go outside of the quality protections of the FDA for their medical care.
Re:Ozempic drug supresses desire to smoke, drink and more by scheme271 on Saturday May 20, 2023 @06:26AM (#36010684)
Nutritional compounds? My understanding is that without a lot of special processing, GLP-1 agonists (semiglutide, liraglutide, tirzepatide, etc) will be degraded by stomach acids into useless fragments. There's an oral semiglutide formulation but it looks like it's quite inefficient and has some pretty strigent requirements in order to be effective.
Re:Ozempic drug supresses desire to smoke, drink and more by reaperman on Saturday May 20, 2023 @11:08AM (#36012538)
What? No one is taking these orally. Hence the bacteriostatic water for injection.

The same distributor sells legal things to import like L-Carnitine, Epitalon, Berberine, NAD+, NACET, and vitamins at great prices so I was saying I use them for things like that.

But others use them for GLP-1 agonists and many do their own independent testing.

Re:Ozempic drug supresses desire to smoke, drink and more by Scoundreller on Saturday May 20, 2023 @01:52PM (#36014026)
> That size filtration will filter out any lifeforms (fungal, bacterial, viral) while allowing the peptide/drug itself to pass through

0.22 won't filter out viruses, but time will inactivate enveloped viruses (which are usually the ones you want to avoid injecting), and source control/proper handling should take care of the rest.