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Re:Faster CPython at PyCon, part one by int_19h on Friday May 12, 2023 @06:42PM (#35923462)
For starters, consider that almost every operator in Python is a dynamic method call under the hood. This includes value equality and hashing, which also affects e.g. dict keys. Oh, and all built-in types can be extended and their behavior overridden.

And then there's descriptors: https://docs.python.org/3/howto/descriptor.html

Re:Faster CPython at PyCon, part one by tgma on Friday May 12, 2023 @10:31PM (#35924903)
Those are hardly unsolvable issues with a JIT as they are static for the vast majority of cases. Solutions have been proposed since the 90s with Self and Strongtalk[1].

Doing that, plus 100% compatibility with CPython extension API, while preserving some expectations of deterministic destruction in Python, are the challenges one would face.

[1]: http://www.strongtalk.org/