Fully automated underground bunkers stocked with precursor pathogens and humanized lab rats equipped with firebombs with the intention of complete evisceration at conclusion of experiment. Dig a deep hole in the desert crane drop in the prepared apparatus wait for experiment results, burn it all down. None of these precautions would prevent someone from using the results of the experiment for ill purposes.

Yes but there is a lot of waste in a system like that and after 10 years of spotless safety record the MBAs will start dismantling it, like re-using facilities instead of firebombing, and the re-fitting inevitably requires some humans on-site etc.

Ok, so put a big fence around it and then find a way to turn people into zombies and fill the fence with said zombies so nobody would even dare go inside the fence.