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Re:Rapamycin: The unlucky history of the most powerful anti-... by tysam_and on Monday May 08, 2023 @03:23AM (#35858996)
Likely if it works, it'll be one piece of the puzzle.

It's not all that hard to try to be honest. Some people have reported absolutely massive changes, some small, some little to none. One or two said decrease but there seemed to be maybe some valid external factors for that.

That's about the distribution one could expect if mitochondrial damage was at play and there was an effective solution for it. Not everyone is going to respond well, likely the older the better if it actually is doing what it says on the tin.

Re:Rapamycin: The unlucky history of the most powerful anti-... by reducesuffering on Monday May 08, 2023 @04:25AM (#35859301)
That's about the distribution one could expect for placebo too.
Re:Rapamycin: The unlucky history of the most powerful anti-... by tysam_and on Monday May 08, 2023 @04:31AM (#35859342)
Could be. Longecity I've found to be an odd mix of people who are rather combative about whether things work or not and who are way too in-depth (in a good way) about their personal experiences about what worked or not.

At the very least, it's intriguing and out of all of the thousands of pages of medical literature I've read over the past half decade or so it's been one of the more interesting sagas to follow.

Re:Rapamycin: The unlucky history of the most powerful anti-... by drBonkers on Monday May 08, 2023 @02:46PM (#35865490)
I have an intuition that if we are to find a solution it is more likely to first sprout from fringe experimentation, such as from Longecity, than the academy.