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Re:Michael J. Fox Foundation Announces Breakthrough for Park... by wyldfire on Monday May 01, 2023 @07:12AM (#35771238)
> 100 mg of thiamine administered intramuscularly twice a week

Is it possible to get anywhere near this much with dietary thiamine?

Re:Michael J. Fox Foundation Announces Breakthrough for Park... by helsinkiandrew on Monday May 01, 2023 @07:37AM (#35771418)
> Is it possible to get anywhere near this much with dietary thiamine?

High thiamine food stuffs have a few milligram at most so it would take some effort. However, many B1 vitamin tablets have 100mg-300mg, although I wonder how well that is absorbed compared with an intramuscular shot - it would seem that you could consume the equivalent of 200mg a week.

Re:Michael J. Fox Foundation Announces Breakthrough for Park... by bitL on Monday May 01, 2023 @08:21AM (#35771789)
I read somewhere that gut can only let around 80mg thiamine/day and gut gets saturated over time, so only IM/IV would work long-term.