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A comment on Study finds new pathway for clearing misfolded proteins. Parent comment

Re:Study finds new pathway for clearing misfolded proteins by nemo44x on Thursday April 20, 2023 @06:10PM (#35647160)
A friend of mine got infected with prions. Well, it’s what the doctors believe since all other tests came up negative. They aren’t 100% sure but have documented it as that.

It’s amazing how quickly he degenerated. He was feeling weird physically and mentally and went to a doctor. Within a few months he was a different person but could recognize friends. He needed assistance for living. Within a year he was completely mentally gone. Just a different person with no means of communicating or doing anything for himself. Just completely sad.

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Re:Study finds new pathway for clearing misfolded proteins by bread90 on Thursday April 20, 2023 @06:54PM (#35647632)
How’d he get it you think?
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Re:Study finds new pathway for clearing misfolded proteins by radicaldreamer on Thursday April 20, 2023 @09:10PM (#35648669)
Here's a case where they're pretty sure it was all the vitamins and supplements in collagen capsules that the patient consumed for years https://n.neurology.org/content/98/18_Supplement/3654
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Re:Study finds new pathway for clearing misfolded proteins by nemo44x on Friday April 21, 2023 @10:44AM (#35654527)
No one has any idea. He wasn’t exposed to anything that would be high risk for it, if that’s even a thing. As another person commented here, it sounds like it’s spontaneous in many cases. Or at least that’s our best answer.
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Re:Study finds new pathway for clearing misfolded proteins by AuryGlenz on Friday April 21, 2023 @02:02AM (#35650229)
You can spontaneously misfold a protein yourself. After a quick look on Wikipedia for Creutzfeldt-Jakob disease: "An EU study determined that "87% of cases were sporadic, 8% genetic, 5% iatrogenic and less than 1% variant."[22]"
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