It works but it's a buggy mess and the newest AMD GPU driver actually regressed and broke it. The most recent build of [Nobara](https://nobaraproject.org/) (a Fedora based gaming distro) works out of the box but if you update it ... You'll break compatibility.

I was able to get VRChat working but when I entered a world with too many avatars I'd see major issues with sound and GPU problems.