Botting can't be prevented anyway due to the analog hole. People are already making HDMI-capture + USB HID emulation devices for that purpose.

Outright manipulation of game-state is a classic computer security issue. Just don't trust the client, calculate that on the server. I believe many games are doing this properly already but especially mobile games still suffer from it because they trust the client more to paper over intermittent connectivity problems.

The information-disclosure kind of cheat, wallhacks and such, can be addressed by game design that minimizes the amount of information exposed to the client.