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Re:P < 0.05 Considered Harmful by nextos on Monday April 10, 2023 @04:55PM (#35517291)
What I have discovered after working in medicine for pretty long is that many biologists and MDs think p-values are a measure of effect sizes. Even a reviewer from Nature thought that, which is incredibly disturbing.

p-values were created to facilitate rigorous inference with minimal computation, which was the norm during the first half of the 20th century. For those who work on a frequentist framework, inference should be done using a likelihood-based approach plus model selection, e.g. AIC. It's makes it much harder to lie.

Re:P < 0.05 Considered Harmful by spekcular on Monday April 10, 2023 @05:14PM (#35517481)
AIC is an estimate of prediction error. I would caution against using it for selecting a model for the purpose of inference of e.g. population parameters from some dataset (without producing some additional justification that this is a sensible thing to do). Also, uncertainty quantification after data-dependent model selection can be tricky.

Best practice (as I understand it) is to fix the model ahead of time, before seeing the data, if possible (as in a randomized controlled trial of a new medicine, etc.).

Re:P < 0.05 Considered Harmful by ramblenode on Monday April 10, 2023 @08:26PM (#35519151)
And it is not uncommon that an intentionally bad model (low AIC) will be used for inference on a parameter when one wants to test the robustness of the parameter to covariates.