My guess is that the publishers would have sued with or without the NEL; they were just waiting to accrue as many infringements as they could in order to force a quick settlement. If you sue immediately there's less damage than if you wait so you can sue for multiple infringements over the whole statute of limitations (3 years AFAIK).
From publisher's/authors' perspectives, there is a massive difference between "controlled digital lending but we respect copyright" and "digital lending, and we can choose to dispense with copyright restrictions whenever we think it is justified".
One of those was an uneasy peace, based on the idea that IA - while it disagreed with the publishers on some issues - was at least acting in good faith. The other one would essentially have gutted all copyright protections, making respecting IP rights purely a matter of choice. Whatever you think of IP and copyright as a whole, publishers were never going to accept that massive change in approach.
That's what they had been doing, for years. Publishers grumbled, but didn't file lawsuits.
It wasn't until the 'National Emergency Library', when IA decided to unilaterally ignore the 'controlled' part of digital lending, that the suit was filed.