No. I've been riding a road tubeless setup in Seattle and surrounding countryside for half a decade now and the feel has nothing to do with Slime. 55mm x ISO 559 lightweight road tires with Orange Seal. (In the NW we like wide road tires : )

Something like 10k miles later I've had zero incidents where I had to fix something on the road. You do have to more maintenance (e.g. make sure you have adequate sealant in the tires periodically) but for regular year round use especially, it is a worthwhile trade.