"Meanwhile" means there isn't any particular connection, but replying in disagreement is very common and on social media it's often assumed if ambiguous.

This seems to happen all the time. Someone is just trying to make conversation (like me, here) and people try really hard to see in what way they were attacked by the comment.

To be fair, I almost always reply in at least mild disagreement, though I try to be friendly about it. I’m doing that now.

If I agree, I upvote and move on.