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Re:Framework announces AMD, new Intel gen, 16“ laptop and more by noveltyaccount on Thursday March 23, 2023 @03:24PM (#35280014)
Seems like pcie connection to the mainboard

> The Framework Laptop 16 has an Expansion Bay system that contains both the cooling fans and an interface for high-power, high-speed PCIe peripherals like GPUs. Expansion Bay modules can extend in both thickness and depth to accomodate higher power requirements.

https://github.com/FrameworkComputer/ExpansionBay

Re:Framework announces AMD, new Intel gen, 16“ laptop and more by nrp on Friday March 24, 2023 @02:52AM (#35285848)
This is correct. We shared the draft pinout in this repository.