Probably enough to mess up your hand, probably not enough to completely remove it. I wouldn't want to count on it for rendering a laptop completely irrecoverable; but it'd probably do a good enough job most of the time.

A "thumb drive" that's much bigger than an m80 is going to be a little suspect anyway, isn't it? some of them things can be swallerd now. Don't think any are designed to work after, alas.