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Re:Dietary sweetener sucralose is a negative modulator of T ... by lr4444lr on Monday March 20, 2023 @06:14AM (#35229475)
Sugar is bad in large quantities.

I've concluded personally that it's still probably the best option - a teaspoon here and there, even daily, probably won't do much if it's near or in a meal. You know what you're getting: simple sugars have been part of the human diet for milennia, and we understand their metabolism reasonably well.

People who use the alternatives are making a much riskier bet on the null hypothesis of future research.

Re:Dietary sweetener sucralose is a negative modulator of T ... by bartvk on Monday March 20, 2023 @06:48AM (#35229728)
Exactly, the summary states "these findings suggest that a high intake of sucralose can dampen T cell-mediated responses". They fed mice the equivalent of the maximum advised dose for humans, 250 mg per kg body weight. So don't do that.
Re:Dietary sweetener sucralose is a negative modulator of T ... by sfjailbird on Monday March 20, 2023 @06:49AM (#35229737)
> simple sugars have been part of the human diet for milennia

The stuff you put in your tea is super concentrated compared to the natural form, though. It takes like 50 kilos of raw sugar cane to make a kilo of table sugar, using an intensive industrial process.