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Re:Launch HN: Pynecone (YC W23) – Web Apps in Pure Python by troymc on Monday March 13, 2023 @11:25PM (#35147012)
These days, in the .NET ecosystem, there is Blazor. You write your whole web app in HTML, CSS and C# (frontend and backend). There are several different deployment models; Wikipedia gives a good summary:

https://en.wikipedia.org/wiki/Blazor

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