Google used to support this[0], and I used it happily for blocking low-quality domains such as Experts Exchange, certain Wikia subdomains, and Pintrest. The feature was later removed[1] in favor of a browser extension, but the extension was less functional because it could only filter out results from the current page, so heavily-spammed keywords had result pages with only one or two links.

Nowadays, with the results being entirely spam for multiple pages, I think a return of the server-side filtering would be necessary if it's to be at all useful. Otherwise you'll get page after page of blank SERPs.

[0] https://searchengineland.com/google-brings-back-blocking-sit...

[1] https://searchengineland.com/googles-more-personalized-resul...