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A comment on Poor Sleep Drove Me Insane, and My Long Path to Recovery. Parent comment

Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by FollowingTheDao on Monday February 27, 2023 @10:36AM (#34957619)
CYP1A2 does not only metabolize caffeine, it is also involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.

Focusing only on caffeine metabolism is one of the pitfalls of 23andme's reports.

This gene change might mean you have higher cholesterol as well.

To see everything this gene does check here: https://www.uniprot.org/uniprotkb/P05177/entry

[ Parent | on HN ]
Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by dangwhy on Monday February 27, 2023 @11:07AM (#34958017)
> This gene change might mean you have higher cholesterol as well.

I have C/C in 23andme like gp and experience same caffeine effects. I have high cholesterol despite being active, fit and good diet.

Would you know of any literature that might explain this in more layman terms. I had hard time reading the link you mentioned.

[ Parent | on HN ]
Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by FollowingTheDao on Tuesday February 28, 2023 @06:47AM (#34968272)
Did this help?

https://jamanetwork.com/journals/jama/fullarticle/202502

CYP1A2 also metabolizes cholesterol so caffeine will increase your heart attack risk.

And this is why genetics are crucial in understanding your dietary risks.

[ Parent | on HN ]
Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by aantix on Tuesday February 28, 2023 @10:47AM (#34970577)
So for those that slowly metabolize caffeine, would it be prudent to take a statin?
[ Parent | on HN ]
Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by FollowingTheDao on Tuesday February 28, 2023 @03:28PM (#34974376)
Probably not. It might be that you need the cholesterol to produce more steroid hormones. Statins not only stop you from making cholesterol but also CoQ10 as well.

It would probably be best to keep a check on your oxidative stress because that is what most likely triggers heart disease, not just cholesterol alone.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769522/

[ Parent | on HN ]