> Are there any other rough edges I should know about?

I think the easiest to encounter is that programs downloaded from the internet might not 'just work' for various reasons. (e.g. because they're linked against libraries in more typical locations, or because the code hardcodes paths like /bin/bash or /bin/rm which NixOS doesn't provide by default).

So, when programs like minikube like to provide a nice UX by downloading helper executables, it won't 'just work'.

Solutions vary from "someone already packaged this, it's not a problem" to requiring deep understanding of what you're trying to do.