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Re:Millions are missing from the workforce due to Covid-19 by maegul on Saturday January 28, 2023 @01:22AM (#34555676)
What's been interesting me with this is how much novelty there is in observing a new pandemic virus hit humanity (or any species for that matter) with the attention and accuracy of modern medicine and population statistics.

It could just be (does anyone know?) that when new viruses pop up like this, the target species often just takes a global health hit that includes not just deaths and acute illnesses but other effects on broader time scales. Maybe this is normal in human, primate or even mammalian history, part of the bumpy evolutionary road, but we didn't really know how much of an effect there is to be had until now, or the soon future?

If true, it's kind of a kick in the guts for modern humanity, as we've probably had a good run on pathogens in recent history (at least globally, with the spanish flu being the obvious recent precedent) and didn't really appreciate that there are still "monsters" lurking out there in Earth's shadows that we're not really "better" than.

I also wonder, if there's truth to the above, to what extent modernity, or at least this (perhaps) middling phase of it, is part of the problem, where high urban population densities can transform what were relatively rare and local pandemics into more common, global and devastating affairs ... ?

Re:Millions are missing from the workforce due to Covid-19 by graeme on Saturday January 28, 2023 @01:50AM (#34555775)
Some have theorized this and there certainly are a few examples. For examples syphllis seemed especially severe when it first appeared in Europe, and this was probably because it was a novel disease.

But thing is it also is just severe and didn’t become just another cold or just another bacteria.

Some viruses just knock a species out, like this virus which gives Tasmanian Devils a lethal facial cancer: https://en.m.wikipedia.org/wiki/Devil_facial_tumour_disease

There’s a lot of just-so stories about how things are bad till your immune system strengthens upon encountering all the viruses and then everything is ok.

Bollocks. Half of kids used to die before adulthood and it was mostly due to disease.

We associate disease as being mostly mild now because we took decisive action over a couple centuries to reduce, treat or prevent the worst diseases.

We were left with the ones that seem inconsequential, and the flu, which was consequential.

The bet is that Sars-cov-2 is inconsequential because it shares a transmission mechanism with the other inconsequential viruses and because it often feels inconsequential in the acute phase.

Hopefully so, we won’t really know the long term effects for a long time. Post-polio syndrome takes decades to manifest in a patient, as does multiple sclerosis from EBV.

Re:Millions are missing from the workforce due to Covid-19 by jacquesm on Saturday January 28, 2023 @03:19AM (#34556104)
> Half of kids used to die before adulthood and it was mostly due to disease.

Yes, and this is why the current strain of anti-vaxx sentiment is so dangerous: if enough people buy into that crap then eventually we'll get below the immunity levels required for these diseases to remain suppressed, there is a noticeable uptick in unvaccinated kids since COVID, about -1% for now which is manageable. But if it would get higher it could lead to trouble.

And then there are the vaccinations that have simply been postponed on account of COVID-19:

https://www.who.int/news/item/22-05-2020-at-least-80-million...

Over time this will eventually be caught up.

Re:Millions are missing from the workforce due to Covid-19 by xyzzy123 on Saturday January 28, 2023 @06:30AM (#34556768)
I think public trust has been eroded by overconfident statements made by authorities, plus the occasional noble lies.
Re:Millions are missing from the workforce due to Covid-19 by jacquesm on Saturday January 28, 2023 @10:07AM (#34558105)
Sure, but a lot of that can only be said in hindsight. That's the hard part: to be right on everything in a fluid situation. It just isn't possible and for every little detail you get wrong there is a small army of well organized detractors that try to use it to destroy everything else as well. What drives those people is still a mystery to me.
Re:Millions are missing from the workforce due to Covid-19 by hypertele-Xii on Saturday January 28, 2023 @04:26AM (#34556349)
The World Health Organization lists pneumonia, diarrhea, and malaria as the leading causes of child mortality globally.

Pneumonia's main risk factor in children is malnutrition. So it's food, not medicine, that's cured the world of child pneumonia.

Diarrhea's main risk factor is contamination of food with feces. Again, the food, and its production, storage, and transport sanitary conditions. Washing with soap is the medicine here, not vaccines.

Malaria's transmission vector is mosquitos. This one you do need a vaccine for, but these mosquitos only exist on the equator.

So while your claim that half of kids used to die mostly due to disease is technically correct, it's actually malnutrition and living in shit that allowed it to happen, and it's our natural immune systems that prevent it (when healthy), not vaccines.

Re:Millions are missing from the workforce due to Covid-19 by quags on Saturday January 28, 2023 @08:18AM (#34557343)
Is that listed for today or for the last 100 years? Because it sounds like this excludes things that vaccines may have solved like small pox, polio and other things a basic vaccine schedule has taken care of. Basically if we exclude diseases that vaccines have reduced or eradicated we are not surprisingly left with things that vaccines do not address.
Re:Millions are missing from the workforce due to Covid-19 by hypertele-Xii on Saturday January 28, 2023 @01:40PM (#34560209)
You are correct, small pox, polio, and rubella are terrifying diseases with vaccines and you should get them.

As we are plagued by media panic over every minor flu, it can be difficult to form an accurate picture of what's actually deadly.

You should still eat healthy though, your immune system evolved precisely to deal with this problem, and it works very well when fed.

Re:Millions are missing from the workforce due to Covid-19 by graeme on Saturday January 28, 2023 @09:35AM (#34557820)
You are using evidence from the present to consider the past. This is not very sensible.

There is a long list of diseases we effectively blocked from killing people:

* Almost anything bacterial

* Measles, mumps, rubella, polio, diphtheria and other commonly immunized childhood diseases

* Smallpox, which we eliminated

No country has anywhere near a 50% child mortality rate now, even when diarrhea and pneumonia are present. They’re the dregs of the scourge of disease we mostly controlled

See here for some descriptions of common childhood diseases of the past: https://www.nature.com/articles/pr200425

Re:Millions are missing from the workforce due to Covid-19 by fidgewidge on Saturday January 28, 2023 @10:23AM (#34558275)
"Smallpox, which we eliminated"

But was it by vaccines? The book "Dissolving Illusions" argues it wasn't, and that smallpox vaccination was a failure similar to the one we just witnessed with COVID vaccines (which are unambiguously a failure by the criteria on which they were originally presented to the populace).

It builds the case by citing many historical texts and news reports from the time when Jenner had first developed his vaccine, showing how it was at first advertised by him as granting 100% immunity only for many cases to emerge where the vaccine failed or outright gave people full smallpox infections. It also shows how the authorities went into denial and became utterly totalitarian, forcing vaccine mandates on people, refusing to accept that Jenner's invention wasn't perfect and forcing children to take it against the will of the parents, some of whom went to prison rather than allow their child to be vaccinated.

It concludes by arguing that smallpox was actually wiped out in the west (along with many other illnesses) by the general improvements in health and sanitation in the 20th century, rather than a vaccine that was very far from being 100% effective.

There was a time when I would have ignored this sort of alternate history take on medical consensus. But having just lived through an event exactly like the one the book describes it all sounds extremely plausible. COVID vaccines went from 95% effective and so clearly able to stop transmission that it was ethical to force people to take it, to "it doesn't stop infection or transmission or sickness, but it does reduce severe disease, let's hope that's not because it's inducing tolerance to spike protein in which case it'll actually be creating more serious disease without that being correctly attributed to the shots".

Re:Millions are missing from the workforce due to Covid-19 by jemmyw on Sunday January 29, 2023 @02:43AM (#34565831)
https://sciencebasedmedicine.org/wrong-about-polio-a-review-...

Lots of tables of figures if you'd like to peruse them, although its more concentrating on Polio. Anyway I guess the point is, yes there is an alternative take, but just because you read that in a book doesn't mean you should believe what you read. A significant amount more research would need to be done and um the author makes enough mistakes to take this with something of a grain of salt.

Re:Millions are missing from the workforce due to Covid-19 by fidgewidge on Sunday January 29, 2023 @08:57AM (#34568110)
I haven't actually read the book, I just know some quotes from it and the gist of what it argues about smallpox.

Anyway, I flicked through the paper. It has a habit of making what it thinks are rebuttals but which either are agreeing with what the book says, or rebuts arguments she didn't actually make. If this is the highest quality sort of rebuttal that's out there then I guess I should read the book because it must be pretty solid.

Example 1. Humphries points out that the vaccine rollout was coincident with a change in how polio was classified, which was guaranteed to significantly reduce the rate at which polio was reported regardless of the vaccine because the prior classification criteria had been very loose. The rebuttal is that yes this is true, but there were still a "significant number" of polio cases being reported after the change. This isn't a real disagreement yet the author uses it to claim that Humphries has callous disregard for polio cases, a nasty ad hominem they constantly repeat. It reduces their own credibility as it's so unlikely to be true. She's a medical doctor, not a profession famous for its callous disregard of disease.

Example 2. Humphries points out that "more than half of the cases [in Michigan] were not polio virus related at all" and the rebuttal is that if you restrict to paralytic polio then that statement isn't true any longer, but, again, that wasn't the claim she made.

Example 3. Another non-rebuttal is to point out that the author of one of the studies she cites was a vaccine fan. So? She was citing the data, not the author's general opinions.

Example 4. The overall thrust of the argument here is that Humphries says the threat of polio was exaggerated, and the author admits this was true (redefinitions, FDR etc), but then claims again that anyone who objects is "callous" and it was OK if FDR was "dramatizing" his illness - which maybe wasn't even polio at all - because it spread awareness. Also that it doesn't matter if polio was actually rare because that's also true of childhood cancer and Americans care about that. Again a non-sequitur of a rebuttal that actually supports the points Humphries was making.

What a crap set of counter-arguments. They don't point out any mistakes, it's just a big set of disagreements over emphasis and tone. If anything this seems to reinforce the overall impression formed in the past two years that pro-vaccine people seem systematically unable to accept that tradeoffs exist, accurate data matters and misleading people to win their support is bad. They also radically over-estimate their own rationality.

Re:Millions are missing from the workforce due to Covid-19 by Izkata on Saturday January 28, 2023 @11:20AM (#34558843)
Polio's death rate was around that of the flu. It was so feared because of the paralyzed survivors, but even that was <1% of infections, not the huge percentage as commonly portrayed nowadays. Around 3/4 of those infected never even had symptoms, and most of the remaining 1/4 only had flu-like symptoms.

On top of that, like the other one GP mentioned, one of its main methods of transmission is feces contamination. It's possible hygiene was also a major factor in stopping it.

Re:Millions are missing from the workforce due to Covid-19 by hypertele-Xii on Saturday January 28, 2023 @01:33PM (#34560132)
> Measles

Fatality rate of 0.2%. Worst fatal complication: Pneumonia, for which the biggest risk factor is immunodeficiency from malnutrition.

> mumps

Fatality rate of 0.04%. Worst fatal complication: Encephalitis, for which the biggest risk factor is immunodeficiency from malnutrition.

> rubella

This one's nasty when it infects a pregnant mother. All women should get rubella vaccinated.

> polio

Fatality rate of up to 30% and debilitating post-effects in up to 50%. You'd be an idiot not to get polio vaccinated.

> diphtheria

Penicillin works.

> Smallpox

Was eliminated with a vaccine that is no longer administered.

You said:

> We associate disease as being mostly mild now because we took decisive action over a couple centuries to reduce, treat or prevent the worst diseases.

My point is that the diseases were bad because there wasn't enough food to maintain healthy immune systems. That's not "decisive action", that's farming and trade. It was the cooking of food and the boiling of water and the washing with soap that prevented deaths from most diseases.

In researching this reply, I've found a respect for some vaccines though. But I still hold food and our natural immunity as the undisputed kings of healthy living.

Re:Millions are missing from the workforce due to Covid-19 by Izkata on Saturday January 28, 2023 @03:02PM (#34561160)
> > polio

> Fatality rate of up to 30% and debilitating post-effects in up to 50%.

Only if you developed paralytic polio. Those percents don't apply to the polio virus in general. Only 3% ever developed anything worse than flu-like symptoms, and paralytic polio was something like 10% of that 3%. (I'm going from memory here, these numbers are on the CDC website)

So we're talking an IFR around 0.1%, very close to the estimated flu IFR of 0.07%

Re:Millions are missing from the workforce due to Covid-19 by graeme on Saturday January 28, 2023 @07:17PM (#34563450)
To be clear: I was talking about the past. The original comment covered the whole breadth of human evolutionary history.

We vanquished these diseases in the past 50-100 years mostly. My argument is that diseases did not just all become benign without intervention

Native Americans, to take one example, were incredibly healthy in their traditional lifestyles. This did not give their immune systems sufficient strength to fight off smallpox and other diseases.

Re:Millions are missing from the workforce due to Covid-19 by theGnuMe on Saturday January 28, 2023 @08:26AM (#34557397)
Untreated syphllis is bad.. It doesn't matter that it is old.
Re:Millions are missing from the workforce due to Covid-19 by 7952 on Saturday January 28, 2023 @03:38AM (#34556162)
On your point about modernity. I think the main risk factor is actually close proximity to animals and poor hygiene around them. That is what allows the rare event of a jump between species to happen. A modern society could reduce this risk a lot.
Re:Millions are missing from the workforce due to Covid-19 by salawat on Saturday January 28, 2023 @05:36AM (#34556587)
...That and not doing Gain of Function research where we deliberately go out of the way to serial passage/DNA clone/chimera viruses to make them more infectious.

Lets be real here. No one hangs out in bat caves for the lulz.

Re:Millions are missing from the workforce due to Covid-19 by 7952 on Saturday January 28, 2023 @07:08AM (#34556944)
You are right, transmission from animals is really difficult. But that also explains why those transferred diseases can be so dangerous. We don't have existing immunity because humans don't hang out in bat caves. And the threat is very real when we live in close proximity to domesticated animals or eat bush meat. And people do both of those things. There is a very long list of infectious diseases that started in animals. We need to be careful. And even in richer countries the threat still exists. People keep chickens in the garden. Environmental surveys look for bats. We have factory farms and abbatoirs.