Not really. The luaTeX engine is the slowest and some of its defaults differ from the behavior of pdfTeX and XeTeX. I generally recommend people use XeTeX (which is also slower than pdfTeX but faster than luaTeX), unless either they specifically need some luaTeX facility or they are required to use pdfTeX (some publishers insist on pdfTeX, although their number is declining. I think that arxiv used to (maybe still does) be one site that only supported pdfTeX, but I could be wrong about that.