Theoretically one could produce ready-to-run, guaranteed clean Python request handlers very quickly. Run all the startup and imports stuff in a Python process, then freeze it. Fork a copy of it on a new request (with COW it's definitely fast), and terminate it normally after that. This would require some care, e.g. to not open sockets before the fork, so that handlers won't share it.

I bet it has been tried, but I'm too lazy to actually search for that.