The one thing that isn't particularly nice is that spheres have intrinsic curvature, essentially if you draw two parallel lines on a sphere they will eventually touch. We can go and look at astronomical data and see if the universe has any intrinsic curvature that we can see.
People did this and it turns out that from all the astronomical data we have the universe looks incredibly, spectacularly flat. No curvature at all that we can detect. This doesn't mean it isn't a sphere, but it means that if it is a sphere it's a really big one. Much much bigger than the observable universe.
But you can have a flat torus (or some other shapes that “wrap around”), but we have different reasons to disbelieve those shapes (the “looks the same in any direction” and “looks the same in every position” expectations).
Cool, thanks!