I have a Python script which I can use to kill all chrome.exe so that next time the machine boots, chrome offers me to restore the tabs which where open before the crash.
I only use this when I know that the tabs are really important and I need to continue using them the next day. Else Chrome starts with a single custom startpage which contains links and as well as views to Jira projects (like a to-do list via the Jira API). And during the day I bookmark all tabs I find important and clean up. But it's usually around 4 windows with each around 10 - 20 tabs which accumulate during the day, in addition to dedicated browser profiles which serve specific purposes, like email or developer consoles.
My current solution is that, through a stroke of luck and a lot of pent up frustration, I've managed to habituate the following behavior:
WHEN I notice I've been procrastinating for too long, OR I'm getting anxious about so many "open loops" in the browser, OR I lose track of specific tabs I know are open and spend more than two seconds looking for it, THEN I find the last Actually Important tab (usually somewhere between the third and the tenth from the left), right-click on it, select "close tabs to the right", and confirm the closure of 100-200 tabs.
I do this a few times on a typical week; because its habituated, I do it fast enough that the FOMO of "but I actually wanted to read that, and that, and that" doesn't have time to kick in.