Frequent breaks, knee pads, using a proper respirator, other ppe? Knee pads make a huge difference for me, at least, and a back brace to encourage proper form when lifting, if I'm doing something that involves a lot of weight.

How can you mitigate burn out/mental health issues caused by lack of human interactions and working in the hugely competitive field?

Stop working from home, go to the office and socialise. Stop comparing yourself to Netflix $900k jobs. Take holidays. Stop side hustling some SaaS app that will never go anywhere.

Get a hobby that isn’t focused on making money. HN isn’t the real world.

Ain't this the truth!

You don't, you do what most of us do and suffer through it, coming out more bitter and broken on the other side. :)

Software development has huge levels of team work and social interaction baked in. And the positions where you don't have that happen to be the ones where no one knows how fast you actually work.