Definitely yes. Over 25 years ago I started a second career, in tech. After 6 months in a Microsoft academic program I got hired by a Big Six accounting firm to do desktop support. My previous education was completely nontechnical (a BA and MA in history, and a JD), as was my experience (10 years as a trial lawyer). No way was I the most qualified on paper for that job, but the people who hired me saw something and acted. A year later I was able to move into a new job with better pay at a Fortune 200 company, originally hired to do applications analysis but shortly after found myself a lead desktop engineer and later a Unix sysadmin. At every turn I was fortunate to have hiring managers that looked beyond my resume to see the potential there.

Sure, in 1997 an HR person told me they needed someone with at least 5 years experience in Windows NT, but in general most interviews I had in the late 90s and early 00s were way less myopic. I'm not sure I'd have the same experience if starting out today.