Could S-modafinil be the new caffeine?

Re:Could S-modafinil be the new caffeine? by PaulHoule on Tuesday January 03, 2023 @11:53AM (#34234010)

I doubt they are separating the two enantiomers, that is very very hard to do. It seems much more likely that have a synthesis which is selective for one or the other.

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Re:Could S-modafinil be the new caffeine? by delton137 on Tuesday January 03, 2023 @05:14PM (#34238892)

Thanks, I included a footnote to elaborate on this. There's actually a paper on how Cephalon produces R-modafinil because they can't just directly synthesize one of the enantiomers. It seems the process does produce both enantiomers (but more R than S ?).. I don't fully understand the process but they have a way of crystalizing out the S enantiomer of modafinil acid and using HPLC..

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