I keep saying primarily because I haven't actually run into any Win32 applications, even large ones (Fusion 360, FreeCAD, Steam), that don't run without them, which is a good sign. I keep saying that as a disclaimer just in case, because I don't want to be on the record saying "it won't" even if it has never happened thus far. So... that's why I recommend VM first. That's why it's important to keep in mind what VCLibs and .NET Native are for, which is UWP and Microsoft Store apps, not Win32 ones, which makes sense for why they wouldn't be affected.