Secession itself tends to massively piss of the country from which one has seceded, which points to why this would be a problem for an independent California (unless it was a “Greater California” including the headwaters and course of the Colorado River, etc.)

In many cases, you see the opposite - a strong public sentiment to allow or even force secession of some territory that is perceived as a "burden". This is usually represented in economic terms - "why do we have to feed X?" - but it can also be motivated by culture, religion, ideology etc (but, quite often, still coached in economic terms).