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Re:Cannabis is legal in most America but federal laws block ... by JumpCrisscross on Saturday December 24, 2022 @11:19AM (#34118238)
The comment you’re responding to is referring to the supremacy clause.
Re:Cannabis is legal in most America but federal laws block ... by AlbertCory on Saturday December 24, 2022 @11:48AM (#34118529)
OP said, "Federal laws do trump state laws in most cases."

That is quite properly nuanced, and "in most cases" means "those cases where the Federal law is constitutional." SCOTUS rules on that issue all the time.