1. Python with htmx has less accidental complexity. It doesn't get rid of intrinsic complexity of the domain, but it does reduce technology-induced overhead.
2. Dotnet/Angular tech split has organisational implications, tending to encourage a division between front end and back end developers. Communication and coordination overhad goes up correspondingly (Conway's law).
3. htmx is stable. There's a lot less churn than with Angular. I haven't measured this, but subjectively, there's less time spent updating packages and re-testing. Keeping FastAPI/Django/Python update is approximately equivalent keeping the dotnet back end up to date.
4. State management is simpler. There's no front end caching to deal with, and so no corresponding cache invalidation questions.
I'm not building tech unicorn sites, so can't comment on whether the technical overhead is justified at that scale. I _have_ been pleasantly surprised at the level of UI sophistication that can be achieved with server side rendering and htmx.
I'm not a big javascript fan generally, so definitely have bias. I also have an increasingly allergic reaction to accidental complexity, so am constantly looking for ways to minimise it.
Based on those biases and experiences, my default starting point is SSR+htmx. In my experience the accidental complexity is lower, productivity higher, and intra-team communication better. YMMV obviously.
Do this in a static functional language and your whole app will more “deterministically pure”.
So yes, it causes more work on backend but, given more tooling, it can provide more opportunities for less code written overall via code-generation (like how creating a model in Rails generates lots of helpers).