I can attest that if you are a migraineur, these things absolutely make a difference. When mine are borderline or I am recovering, changing the colour and redshift on my monitors can make the difference between being able to do some work and triggering a full blown headache. It's as noticeable as someone turning up the volume on a sound to me.

Whether it matters to all the people all the time is a different question. But it 100% makes a big difference to many people.