There are some people, including some modern Ukrainians, who claim that Ukraine is a continuation state of people who had always lived in that area and have founded Kiev (I assume that it wat this 'ancient Ukraine' you were referring to here [0]). In that case, yes, 'Ukraine' was 'harassed' by itself, as Russia is nothing else, but a state created by this 'ancient Ukraine'.

If you hold another opinion - that Ukrainians are mixed descendants of people who came to live in this area in ~15 century after it was devastated by Mongol invasions and later steppe nomads plundering in 13..14 centuries, then no, Russia could not have harassed it in 'ancient' times.

[0]: https://news.ycombinator.com/item?id=33948877