My ISP (Metronet, Ohio, US) uses CGNAT. I’ve had their service for about 15 months now, and it has been pretty much uneventful. Maybe a handful of times I’ve gotten a captcha on something, but for the most part, it’s just fine. I also don’t see thousands of blocked connection attempts a day either, so there is a plus side. I just use Tailscale should I need to access anything at home while I’m away.