I don't think it necessarily has to be about giving up, but it makes a lot of sense that if you already sort of hate your employer, them deciding to throw out a bunch of valuable work you did and lay you off is a good incentive to reconsider your current industry or at least take a break.

Personally I had an entire year worth of difficult sweng work thrown out due to politics, and it's impossible for that not to negatively impact my mood (or performance reviews)!