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Re:Ask HN: Anyone try semaglutide / Wegovy for weight loss? by windpower on Thursday November 24, 2022 @12:38PM (#33733986)
I’m not on semaglutide, but I am on tirzepatide (aka Mounjaro), which is the newest drug in the same class.

Honestly, it’s like a miracle. I’ve been fat since I was 6 years old. I’ve occasionally lost weight (though never made it to “normal”), but only through pretty intense, focused effort to restrict calories. I’ve always gained it back (and then some) after I can’t sustain that effort. (Call it lack of willpower or whatever, but this is how it works for the vast, vast majority of people.)

Anyway, on tirzepatide, it’s simply effortless. Food is still good, and I still like to eat, but I don’t think about it all day. I eat a reasonable amount, feel full, and don’t have the urge to eat again for hours and hours. That’s honestly a new experience for me. My entire life “eat when you’re actually hungry” would have meant eating all day every day, basically. I’ve been losing weight at a consistent 2.5 lbs / week on this drug. I fully intend to be on it for the rest of my life (or other drugs in the class as they come out).

As for side effects: I’ve had precisely none. No nausea, constipation, heartburn, etc. I understand those are common but I haven’t experienced them at all.

Re:Ask HN: Anyone try semaglutide / Wegovy for weight loss? by issa on Thursday November 24, 2022 @12:51PM (#33734146)
I feel like I could have written this myself. And I am also fairly certain that someday the cause(s) of this constant hunger will be identified and we'll someday be spared of people criticizing our "willpower".
Re:Ask HN: Anyone try semaglutide / Wegovy for weight loss? by e1g on Thursday November 24, 2022 @02:41PM (#33735403)
Similar story. I did a medically supervised weight loss phase assisted by Mounjaro, which worked shockingly well for me. Very low calorie (800-1,000 per day), but still high energy and no hunger even under pressure. Steady blood sugar ( have a GCM just for fun), consistent weight loss, and no side effects.
Re:Ask HN: Anyone try semaglutide / Wegovy for weight loss? by toomuchtodo on Thursday November 24, 2022 @11:41PM (#33739250)
What was the difficulty level in getting tirzepatide prescribed?
Re:Ask HN: Anyone try semaglutide / Wegovy for weight loss? by windpower on Friday November 25, 2022 @02:06AM (#33739995)
I asked my doctor about it and they prescribed it. They had previously prescribed Wegovy/semaglutide but it’s very supply constrained right now so I was never able to actually take it.