I say it's especially true with stimulants not because of some perceived safety, but because at the start of taking stimulants you will feel great. This generally wears off within a few weeks and never comes back. The test of whether stimulant medications help you isn't if they help you at the start, it's how you feel about them six months in.

edit: feeling great only applies to some stimulant medications and seems to vary from person to person. Personally, I hated the pharmaceutical stimulant experience but they still helped me. I would be taking meds right now if I could afford it.