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Re:My ADHD Founder Toolbox by sn41 on Wednesday November 16, 2022 @11:22PM (#33634934)
I think you are a bit premature in your assessment. The first month usually works for most people. Later on, you may find that it has no effect, worse, you start developing a dependency. People don't give up medication due to ideals or laziness, many find that the disease is often manageable using less addictive approaches like CBT.

That said, if medications cure you altogether, there's nothing better. But ADHD, unlike other conditions, seems to relapse a lot.

Re:My ADHD Founder Toolbox by mtsr on Thursday November 17, 2022 @01:20AM (#33635632)
Do you wear glasses? Would you say you have a dependency on them? I know my wife does. So what?

Again with the stigma.

There’s little medical reason to expect stimulant effectiveness to change after the first couple of weeks, the “honeymoon period”, during which the mood lifting effects are most pronounced. It’s also that same effect that is the main attraction for abusers because it can give euphoria in high enough doses. And yes, that mostly goes away.

But other than a possible slight increase in dopamine re-uptake due to a long term increase in dopamine (over what’s initially a dopamine deficiency as far as we know), there’s no long term habituation (as far as we know).

If you feel better without medication, that’s fine, but please don’t guilt others into throwing away their metaphorical glasses.

Re:My ADHD Founder Toolbox by sedivy94 on Thursday November 17, 2022 @02:24AM (#33635958)
Are you not aware that dopamine receptor density increases over time with amphetamine use? Amphetamine may be a net positive for some folks despite this, but for others it actually exacerbates the condition over time.
Re:My ADHD Founder Toolbox by mtsr on Thursday November 17, 2022 @02:31AM (#33635990)
I think it’s a decrease of receptors or an increase of re-uptake. But yes, there have been results pointing in that direction, but as far as I’m aware this is not as clear as that. Who does it affect? Is it seen with abusers or with users of (generally much lower dosed) meds? How much? How does this compare to the dopamine deficiency we see without treatment? Etc. But if you have a good and recent source, I’d love to read it.
Re:My ADHD Founder Toolbox by dr_dshiv on Thursday November 17, 2022 @02:30AM (#33635986)
Cite please?
Re:My ADHD Founder Toolbox by sirsinsalot on Thursday November 17, 2022 @04:19AM (#33636630)
You're misunderstanding the action of the medication and the defect in the brain of adhd. Adhd is an abnormal density of dopamine transporter.

Receptor density might increase, but that's negligible in the system compared to the starting density of transporters at therapeutic doses.

Re:My ADHD Founder Toolbox by benibela on Thursday November 17, 2022 @11:07AM (#33640906)
I have been wearing glasses against nearsightedness/astigmatism since I am an adult.

I already needed them as teenagers, but my mother was against it, because I should not grow too dependent on them. Because she says if you wear glasses, the eye adjust to the glasses, so you see as bad with the glasses, as you did without glasses. Then you need stronger glasses, and every time you get stronger glasses, they make the eyes worse, until they make you almost blind. The opticians are destroying your eyes on purpose, so they can sell more glasses

I only got glasses as adult because it was mandatory to get a driving license. I actually got an anxiety attack in the driving exam and failed the exam, when I had to put my glasses on because I was still convince they make you blind.

I wonder if I have ADHD, too. I am completely unable to participate in classes, but my grades in exams were good enough that no teacher suggested testing. It is like I have zero attention on anything said in class, but then hyperfocus on reading/writing/programming stuff. Anyways my mother would not have allowed me to go to a psychiatrist, because she think that psychiatry is a scam. The psychiatrists are only trying to get you addicted to drugs and destroy your health on purpose, so they can sell more drugs.

Or it might be because I could not see anything in class. Then I had to stare at something and try to recognize something in the blur, and that was taking away all my attention. But reading things in close range worked fine without glasses. Perhaps degraded sensory input is actually a cause for ADHD. The brain diverts too much processing power on processing sensations, and there is not enough processing power left for the actual task, and it makes any sensation (distraction) appear much more important. I still cannot participate in classes even with glasses

Re:My ADHD Founder Toolbox by Skgqie1 on Thursday November 17, 2022 @01:24AM (#33635651)
For me, I've been on dexamphetamine sulphate for about five years. I had to have my dose adjusted after about a year, because I experienced what you mentioned (decreased efficacy). Once the dose was increased, the effect became pretty stable though (I'm currently on 45mg a day). I wouldn't say it completely negates my ADHD, but it definitely makes things a lot more manageable.
Re:My ADHD Founder Toolbox by Jarwain on Thursday November 17, 2022 @01:59AM (#33635842)
What did your dose look like at the start? & how did it progress over the 5 years?
Re:My ADHD Founder Toolbox by Skgqie1 on Thursday November 17, 2022 @06:54AM (#33637715)
I believe it was 30mg (10mg, 3x a day) that I started on. Dosage was adjusted after about a year, when I began to notice the dosage wasn't really having the same effect. Was upped to my current dose that I've been on since then.