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Re:A gut-derived hormone suppresses sugar appetite/regulates... by AnIdiotOnTheNet on Sunday November 13, 2022 @01:16PM (#33585695)
And yet Mark Haub[0] ate a diet of Twinkies (and other convenience store garbage food) to a caloric deficit and lost 27lbs in 10 weeks while all of his health metrics improved.

Trying to be super precise about calories may be complicated, but nobody has to do that to reach a caloric deficit anyway so who cares. Eat less than you need by any reasonable ball park metric and you will lose weight, it's that simple.

The hard part is that for some reason a large percentage of the population can't regulate their intake naturally because what they require for calories to be a healthy weight is misaligned with what they are compelled to consume.

[0] http://www.cnn.com/2010/HEALTH/11/08/twinkie.diet.professor/...

Re:A gut-derived hormone suppresses sugar appetite/regulates... by klyrs on Sunday November 13, 2022 @01:52PM (#33586112)
Sure, let's agree that CICO is a decent rule of thumb, not a law. That's a fun anecdote, though.