I mean, aerodynamic drag scales linearly with both Cd and A. It isn’t too far-fetched to think that you might be able to trade them off in a blended wing design and come out ahead by reducing interference drag and wetted surface area.

The pressure vessel problem is much more concerning to me—I can’t think of a way to solve it that wouldn’t massively increase weight and/or reduce usable space.

To be fair, the B2/737 comparison isn’t particularly fair—they were optimized for wildly different things, and only one design was significantly constrained by acquisition and operational costs.