Given that Safe Browsing is used in other browsers, and that you can disable that feature and/or change your default search engine, yes it does matter.

Also, even if you are using Chrome with the default search settings, there are lots of cases where it would matter. I suspect people would care a lot more about Google logging the URL for their Amazon search for <embarrassing thing they purchase> than when they typed `amazon.com` in their URL bar to get to Amazon.