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Re:Ask HN: How did you find joy in life? by manmal on Sunday October 30, 2022 @05:45PM (#33399090)
Some things to take into consideration:

- Optimizing the microbiome. There’s tons of studies around various strains and methodologies etc. You could benefit from just eating no sugar and more fiber, or you could be in need of a fecal matter transplant. Unfortunately the microbiome and its effects on health is still not that well understood.

- Light therapy, or photobiomodulation with near-infrared light has some promising studies. I’ve personally used it to great effect.

- Magnesium supplementation has been shown to work in some treatment-resistant cases (obviously only works if you’re deficient). Mg is quickly eliminated via kidneys, so lower doses spread over the day might work better.

- Check Glycine levels (or just try a supplement, it’s cheap). Low levels are linked to depression. It also improves sleep usually, a nice side effect.

- Anything that lowers inflammation in the brain could work well in treatment resistant depression.

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