> Based on this combination of factors, the available evidence appears to be inconsistent with both historic precedent and the scientific understanding of how natural zoonotic spillovers of respiratory viruses like SARS-CoV-2 occur. Ultimately, without increased transparency and publicly available and reproducible evidence that addresses these missing pieces of evidence, it is difficult to support the natural zoonotic origin hypothesis for the SARS-CoV-2 outbreak and COVID-19 pandemic.