Using M1 plus the address lines was used to trap on certain addresses on expansion devices for the Spectrum such as Interface 1 or the +D. Then they’d use a line on the expansion bus to disable the standard ROM and substitute their own ROM / static RAM until some other trigger such as an OUT to a port would page the ROM back in.

I guess it’s a short step to looking up memory addresses against a bitmap for validation. I couldn’t tell from the video if this is what he did. Cutting the addresses into pages would let you save or add more levels and I guess you could implement a TLB similarly.